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Updated: Aug 14, 2026

Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function
Published on: November 4, 2016
Transcriptional control of cytokine genes
1Department of Molecular and Developmental Biology, University of Tokyo, Japan.
Abstract:
With antigen stimulation, cytokine genes are coordinately expressed in T cells. However, the optimal signals or helper T cell subset specificity for each cytokine gene expression differ. Mechanisms probably exist that transmit extracellular signals into the nucleus, thereby coordinately turning on and off transcriptional machinery in a signal-specific or cell type-specific manner. We compare here the regulation of cytokine genes and discuss possible mechanisms of coordinated and differential regulation of cytokine genes.
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