Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin 8 can affect inner ear function

H Iguchi1, M Anniko

  • 1Department of Otorhinolaryngology and Head and Neck Surgery, Uppsala University Hospital, Sweden.

ORL; Journal for Oto-Rhino-Laryngology and Its Related Specialties
|July 1, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smallest Optical Gap for Pt(II)-Pt(IV) Mixed-Valence Pt-Cl and Pt-Br Chain Complexes Achieved by Using a Multiple-Hydrogen-Bond Approach.

Inorganic chemistry·2018
Same author

Randomised phase II trial of irinotecan plus S-1 in patients with gemcitabine-refractory pancreatic cancer.

British journal of cancer·2017
Same author

Diagnosis and treatment of bone metastasis: comprehensive guideline of the Japanese Society of Medical Oncology, Japanese Orthopedic Association, Japanese Urological Association, and Japanese Society for Radiation Oncology.

ESMO open·2016
Same author

A randomized phase II study of S-1 plus oral leucovorin versus S-1 monotherapy in patients with gemcitabine-refractory advanced pancreatic cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2015
Same author

Investigation of a high spatial resolution method based on polar coordinate maximum entropy method for analyzing electron density fluctuation data measured by laser phase contrast.

The Review of scientific instruments·2012
Same author

Comparative risk of common peroneal nerve injury in far anteromedial portal drilling and transtibial drilling in anatomical double-bundle ACL reconstruction.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2011
Same journal

Quality-of-Life and Cosmetic Outcomes With Endoscopic Versus Microscopic Endaural and Postauricular Type I Tympanoplasty.

ORL; journal for oto-rhino-laryngology and its related specialties·2026
Same journal

Posterior Nasal Neurectomy for Allergic and Non-Allergic Rhinitis: Efficacy, Safety, and Predictive Factors.

ORL; journal for oto-rhino-laryngology and its related specialties·2026
Same journal

COGNITIVE FUNCTION AND OLFACTORY ABILITY IN THE ELDERLY: AN ASSOCIATION ANALYSIS.

ORL; journal for oto-rhino-laryngology and its related specialties·2026
Same journal

Risk Factors for Intubation-Related Laryngeal Granulomas: A Prospective Study in Surgical Patients.

ORL; journal for oto-rhino-laryngology and its related specialties·2026
Same journal

Surface Texture of Taste Carriers Modulates Bitter Taste Identification.

ORL; journal for oto-rhino-laryngology and its related specialties·2026
Same journal

Characteristic analysis of laryngopharyngeal reflux-related mucosal vessels under narrow band imaging laryngoscopy.

ORL; journal for oto-rhino-laryngology and its related specialties·2026
See all related articles

Interleukin 8 (IL-8) instillation in rat ears caused temporary high-frequency hearing loss and inflammation near the round window membrane. Hearing returned to normal within 14 days, suggesting IL-8 influences inner ear function.

Area of Science:

  • Otolaryngology
  • Immunology
  • Neuroscience

Background:

  • Interleukin 8 (IL-8) is a key chemokine in inflammatory responses.
  • The round window membrane (RWM) is a critical interface between the middle and inner ear.
  • Understanding the effects of middle ear inflammation on inner ear function is crucial for auditory health.

Purpose of the Study:

  • To investigate the electrophysiological and morphological effects of IL-8 instillation on rat inner ear function.
  • To determine the time course of hearing changes and inflammatory responses following IL-8 exposure.

Main Methods:

  • Electrophysiological assessment using frequency-specific auditory brainstem response (ABR) in rats.
  • Morphological examination of the inner ear structures via light microscopy.

Related Experiment Videos

  • Controlled instillation of IL-8 into the round window niche via tympanic membrane perforation.

    • Main Results:

    • Significant elevation in ABR thresholds observed at high frequencies (16-20 kHz) by day 2 and mid-frequencies (10-12 kHz) by day 5.
    • Hearing thresholds returned to baseline levels by day 14.
    • Inflammatory cell infiltration (neutrophils, macrophages) observed around the RWM, with no apparent damage to the organ of Corti or stria vascularis.

    Conclusions:

    • Middle ear IL-8 instillation can induce temporary, high-frequency sensorineural hearing loss in rats.
    • The inflammatory response is localized around the RWM, without direct cochlear damage.
    • IL-8 plays a role in modulating inner ear function during middle ear inflammation.