Novel anticoagulants based on direct inhibition of thrombin and factor Xa

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents.

Neuropharmacology·2011

Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis.

Journal of thrombosis and haemostasis : JTH·2010

Effect of tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis.

Journal of thrombosis and haemostasis : JTH·2008

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain.

The Journal of biological chemistry·2001

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Nature·2000

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.

Proceedings of the National Academy of Sciences of the United States of America·2000

Long-term outcome between two different revascularization strategies for patients with left main coronary artery disease and concomitant chronic total occlusion of right coronary artery disease.

Coronary artery disease·2026

The perforation triad as a recognition-and-response pattern for balloon- or stent-related Ellis II-III coronary artery perforation during percutaneous coronary intervention.

Coronary artery disease·2026

Radiation burden in chronic total occlusion percutaneous coronary intervention is driven more by lesion complexity and planned strategy than by the target vessel.

Coronary artery disease·2026

Combined triglyceride-glucose index and systemic inflammation for long-term risk stratification in major adverse cardiovascular events: a 10-year prospective study.

Coronary artery disease·2026

Deconditioning in coronary artery disease: an underrecognized problem with contemporary clinical relevance.

Coronary artery disease·2026

Intracoronary supersaturated oxygen therapy after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: a systematic review and meta-analysis.

Coronary artery disease·2026

Bergamottin: a multitarget natural furanocoumarin with promising anticancer potential.

Translational cancer research·2026

Targeting liver angiotensinogen with siRNA enhances podocyte regeneration through renin lineage cells in experimental kidney disease.

Molecular therapy. Nucleic acids·2026

AaSnRK2.6 interacts with AaORA to positively regulate artemisinin biosynthesis in Artemisia annua.

Horticulture research·2026

Intramolecularly quenched fluorogens enable multispectral activation with a fluorescein-targeting single-chain variable fragment.

Organic & biomolecular chemistry·2026

Related Experiment Videos

Novel anticoagulants based on direct inhibition of thrombin and factor Xa

Related Concept Videos

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents.

Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis.

Effect of tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis.

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain.

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state.

Long-term outcome between two different revascularization strategies for patients with left main coronary artery disease and concomitant chronic total occlusion of right coronary artery disease.

The perforation triad as a recognition-and-response pattern for balloon- or stent-related Ellis II-III coronary artery perforation during percutaneous coronary intervention.

Radiation burden in chronic total occlusion percutaneous coronary intervention is driven more by lesion complexity and planned strategy than by the target vessel.

Combined triglyceride-glucose index and systemic inflammation for long-term risk stratification in major adverse cardiovascular events: a 10-year prospective study.

Deconditioning in coronary artery disease: an underrecognized problem with contemporary clinical relevance.

Intracoronary supersaturated oxygen therapy after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction: a systematic review and meta-analysis.

Bergamottin: a multitarget natural furanocoumarin with promising anticancer potential.

Targeting liver angiotensinogen with siRNA enhances podocyte regeneration through renin lineage cells in experimental kidney disease.

AaSnRK2.6 interacts with AaORA to positively regulate artemisinin biosynthesis in Artemisia annua.

Intramolecularly quenched fluorogens enable multispectral activation with a fluorescein-targeting single-chain variable fragment.

Related Experiment Videos

Novel anticoagulants based on direct inhibition of thrombin and factor Xa

Related Concept Videos

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