Related Experiment Videos
Xanthine oxidase reaction with nitric oxide and peroxynitrite
1Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35233-6810, USA.
Archives of Biochemistry and Biophysics
|July 2, 1998
Abstract:
Nitric oxide (.NO) and peroxynitrite (ONOO-) inhibit enzymes that depend on metal cofactors or oxidizable amino acids for activity. Since xanthine oxidase (XO) is a 2(2Fe2S) enzyme having essential sulfhydryl groups linked with Mo-pterin cofactor function, the influence of .NO and ONOO- on purified bovine XO was determined. Physiological (