Related Experiment Videos
Fucosyltransferase-catalyzed formation of L-galactosylated Lewis structures
K Stangier1, M M Palcic, D R Bundle
1Department of Chemistry, University of Alberta, Edmonton, Canada.
Carbohydrate Research
|July 2, 1998
Abstract:
The Lewis (alpha 1-3/4) fucosyltransferase isolated from human milk could be used for preparative fucosylations of the disaccharide acceptors Gal(beta 1-3)GlcNAc(beta 1-O)R (at position OH-4) and Gal(beta 1-4)GlcNAc(beta 1-O)R (at position OH-3) [R = (CH2)8COOMe]. As donors GDP-L-Gal and deoxygenated derivatives were used to lead to a series of novel modified trisaccharides of the Lewis(a) and the Lewis(x) type, respectively.