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Updated: Aug 12, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
[Pathogenesis of osteoporosis and risk factors]
1Dept. of Geriatrics, Faculty of Med., Univ. of Tokyo.
Abstract:
Osteoporosis is defined as a disease with low bone mineral density (BMD) and the increased probability for non-traumatic fractures in elderly. BMD in the elderly is theoretically determined by the BMD reached in younger era and the rate of bone loss in the later life. Both of peak bone mass and bone loss rate are known to be affected by environmental factors as well as genetic factors. In addition, both factors are assumed to interact each other. Prevention and treatment of osteoporosis would be fascilitated by understanding both of these factors.
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