Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development of vibrating flow pump for left ventricular assist circulation

S Kobayashi1, S Nitta, T Yambe

  • 1Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

The International Journal of Artificial Organs
|July 2, 1998
PubMed
Summary

A novel vibrating flow pump (VFP) effectively assists the left ventricle in goats, demonstrating sufficient performance for ventricular assist devices. This high-frequency pump shows promise for developing smaller blood pumps.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic significance of histologic parameters of soft tissue sarcomas.

Cancer·1992
Same author

A reassessment of histologic classification and an immunohistochemical study of 88 retinoblastomas. A special reference to the advent of bipolar-like cells.

Cancer·1992
Same author

[Elemental analysis of hilar and mediastinal lymph nodes in idiopathic pulmonary fibrosis].

Nihon Kyobu Shikkan Gakkai zasshi·1992
Same author

Relationship between inhibitor of extrathyroidal 5'-deiodinase activity and serum free fatty acid in children with nonthyroidal illness and acute ketosis.

Endocrinologia japonica·1992
Same author

[Changes in seizure-triggering threshold and after discharge duration in seizure susceptibility].

No to shinkei = Brain and nerve·1992
Same author

Mechanism of extracellular ATP-stimulated phosphoinositide hydrolysis in rat glioma C6 cells.

The Journal of pharmacology and experimental therapeutics·1992

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Devices

Background:

  • Ventricular assist devices (VADs) are crucial for managing heart failure.
  • Existing VADs face challenges related to size, durability, and physiological compatibility.
  • High-frequency pulsatile flow may offer advantages in hemocompatibility and device miniaturization.

Purpose of the Study:

  • To develop and evaluate a new type of vibrating flow pump (VFP) as a ventricular assist device.
  • To assess the hemodynamic performance of VFP in a preclinical animal model.
  • To determine the feasibility of using VFP for left ventricular assistance.

Main Methods:

  • A novel VFP was designed and implemented as a left ventricular assist circulation.
  • Aseptic animal experiments were conducted using goats under awake conditions.

Related Experiment Videos

  • Continuous hemodynamic monitoring and frequency analysis (Fourier transformation) of blood flow waveforms were performed.

    • Main Results:

    • The VFP operated at a driving frequency of 25 Hz, delivering approximately 2 L/min flow rate.
    • Frequency analysis revealed a peak power at 25 Hz, correlating with the VFP's driving frequency.
    • Systemic vascular resistance decreased during VFP-assisted circulation, and no fatal arrhythmias were observed.

    Conclusions:

    • The new VFP demonstrates sufficient performance for left ventricular assistance.
    • The high-frequency, short-stroke volume mechanism of VFP may enable the development of smaller blood pumps.
    • VFP technology shows potential as a next-generation ventricular assist device.