Dose intensity: its limitation and the M. D. Anderson Cancer Center's view of its application

Therapy for germ cell tumors has been viewed as a model of successful treatment development in solid tumors. Despite this, treatment remains unsatisfactory in patients with poor risk or high volume at initial presentation. Present strategies under investigation include the use of dose intensification through the shortening of treatment intervals and the dose escalation of agents with a presumed dose-response relationship in the presence or absence of bone marrow transplant or stem cell support.