Physical constraints in the synthesis of glycogen that influence its structural homogeneity: a two-dimensional...

Several aspects of glycogen optimization as an efficient fuel storage molecule have been studied in previous works: the chain length and the branching degree. These results demonstrated that the values of these variables in the cellular molecule are those that optimize the structure-function relationship. In the present work we show that structural homogeneity of the glycogen molecule is also an optimized variable that plays an important role in its metabolic function. This problem was studied by means of a two-dimensional approach, which allowed us to simplify the very complicated structure of glycogen. Our results demonstrate that there is a molecular size limit that guarantees the structural homogeneity, beyond which the structure of the molecule degenerates, as many chains do not grow. This strongly suggests that such a size limit is precisely what the molecule possesses in the cell.