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Related Experiment Videos

Evaluating gene flow using selected markers: a case study

T Lenormand1, T Guillemaud, D Bourguet

  • 1Laboratoire Génétique et Environnement, Institut des Sciences de l'Evolution (UMR 5554), Université Montpellier II, 34095 Montpellier Cedex 5, France. lenorman@isem.univ-montp2.fr

Genetics
|July 3, 1998
PubMed
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Local adaptation in mosquitoes depends on migration and selection. Studying two resistance loci in Culex pipiens pipiens revealed gene flow, selection pressures, and fitness costs, explaining adaptation maintenance.

Area of Science:

  • Evolutionary biology
  • Population genetics
  • Ecology

Background:

  • Local adaptation is shaped by selection, migration, and pocket size.
  • Multiple loci involved in adaptation complicate the disentanglement of evolutionary forces.

Purpose of the Study:

  • To investigate local adaptation to organophosphate insecticides in Culex pipiens pipiens.
  • To disentangle the roles of migration and selection using frequency gradients and linkage disequilibrium.
  • To estimate gene flow, selection pressure, and fitness costs associated with resistance loci.

Main Methods:

  • Analysis of frequency gradients at two resistance loci.
  • Assessment of linkage disequilibrium between loci.
  • Estimation of gene flow and selection intensity.

Related Experiment Videos

  • Quantification of fitness costs associated with insecticide resistance.

    • Main Results:

    • Estimated gene flow and selection pressure on insecticide resistance.
    • Quantified fitness costs for each resistance locus.
    • Identified the interaction effects between the two resistance loci.
    • Determined conditions for maintaining the local adaptation pocket.

    Conclusions:

    • The study successfully disentangled migration and selection forces.
    • Estimates provide insight into the maintenance of insecticide resistance in Culex pipiens pipiens.
    • Understanding locus interactions is crucial for predicting adaptation dynamics.