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The voltage dependence of a cloned mammalian renal type II Na+/Pi cotransporter (NaPi-2)
I Forster1, N Hernando, J Biber
1Physiologisches Institut, Universität Zürich, CH-8057 Zürich, Switzerland. forster@physiol.unizh.ch
The Journal of General Physiology
|July 3, 1998
Abstract:
The voltage dependence of the rat renal type II Na+/Pi cotransporter (NaPi-2) was investigated by expressing NaPi-2 in Xenopus laevis oocytes and applying the two-electrode voltage clamp. In the steady state, superfusion with inorganic phosphate (Pi) induced inward currents (Ip) in the presence of 96 mM Na+ over the potential range -140