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Sweet's syndrome associated with cutaneous T cell lymphoma
F Aubin1, M P Dufour, R Angonin
1Department of Dermatology, University Hospital, 2, place Saint-Jacques, 25030 Besançon Cedex, France. francois.aubin@univ-fcomte.fr
European Journal of Dermatology : EJD
|July 3, 1998
Summary
Sweet's syndrome is rarely linked to T cell lymphoma. This study details the first documented case of Sweet's syndrome occurring with cutaneous T cell lymphoma, suggesting a cytokine-driven process.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Sweet's syndrome, an acute febrile neutrophilic dermatosis, is often associated with hematologic malignancies and solid tumors.
- Previous reports of Sweet's syndrome linked to T cell lymphoma are scarce, with only two documented cases.
Observation:
- This report presents the first observed case of Sweet's syndrome in conjunction with cutaneous T cell lymphoma.
- The patient's presentation involved characteristic dermatological and systemic symptoms of Sweet's syndrome.
Findings:
- The study suggests a potential role for a cytokine cascade initiated by an abnormal T cell clone in the pathogenesis of this association.
- Neutrophil infiltration, a hallmark of Sweet's syndrome, is proposed to be a secondary event triggered by these cytokines.
Implications:
- This finding expands the known spectrum of hematologic malignancies associated with Sweet's syndrome.
- Understanding the cytokine-mediated pathway may offer new therapeutic targets for managing Sweet's syndrome in the context of T cell lymphoma.