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Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Ventricular remodeling and its prevention in the treatment of heart failure

R D Patten1, J E Udelson, M A Konstam

  • 1Department of Medicine, New England Medical Center, Boston, MA 02111, USA.

Current Opinion in Cardiology
|July 3, 1998
PubMed

Insights

Left ventricular remodeling after heart injury is a harmful process. Angiotensin-converting enzyme (ACE) inhibitors and beta-blockers can prevent this remodeling and improve patient survival.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Ventricular remodeling involves changes in left ventricular (LV) geometry, mass, and volume.
  • LV remodeling after myocardial infarction or in heart failure predicts morbidity and mortality.
  • LV remodeling is recognized as a maladaptive process.

Purpose of the Study:

  • To review the role of pharmacologic agents in inhibiting left ventricular remodeling.
  • To highlight the impact of angiotensin-converting enzyme (ACE) inhibitors and beta-blockers on LV remodeling and survival.

Main Methods:

  • Review of existing data and studies on drug efficacy in preventing LV remodeling.
  • Analysis of the role of the renin-angiotensin and sympathetic nervous systems in cardiac remodeling.

Main Results:

  • Angiotensin-converting enzyme (ACE) inhibitors demonstrate significant benefits in improving survival and preventing progressive LV remodeling.
  • Beta-adrenergic blockers also show a positive effect on both survival and remodeling.
  • The renin-angiotensin system and sympathetic nervous system are implicated as causative factors in LV remodeling.

Conclusions:

  • ACE inhibitors should be a standard treatment for patients with LV dysfunction to prevent remodeling.
  • Beta-blockers may also be beneficial and should be considered in the pharmacologic regimen.
  • Targeting the renin-angiotensin and sympathetic nervous systems is crucial for managing LV remodeling.

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