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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Nutritional issues in inflammatory bowel disease

L A Dieleman1, W D Heizer

  • 1Department of Medicine, University of North Carolina, Chapel Hill, USA.

Gastroenterology Clinics of North America
|July 3, 1998
PubMed
Summary
This summary is machine-generated.

Malnutrition is prevalent in inflammatory bowel diseases (IBD). This review covers its causes, consequences, and the effectiveness of nutritional support, including specific nutrients like glutamine and fish oil.

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Area of Science:

  • Gastroenterology and Clinical Nutrition

Background:

  • Malnutrition is a significant complication in patients diagnosed with chronic inflammatory bowel diseases (IBD).
  • Understanding the multifaceted causes and severe clinical consequences of malnutrition in IBD is crucial for effective patient management.

Purpose of the Study:

  • To comprehensively review the incidence, etiological factors, and clinical impact of malnutrition in individuals with IBD.
  • To evaluate the efficacy of various nutritional support strategies, including enteral and parenteral nutrition, as primary or adjunctive therapies for IBD-related malnutrition.

Main Methods:

  • Review of existing literature, including past and recent controlled studies, focusing on nutritional interventions in IBD.
  • Analysis of data pertaining to the roles of specific nutritional components such as glutamine, short-chain fatty acids, and fish oil.

Main Results:

  • Malnutrition is frequently observed in IBD patients, stemming from various factors and leading to adverse clinical outcomes.
  • Nutritional support, delivered enterally or parenterally, demonstrates a role in managing malnutrition in IBD.
  • Specific nutrients like glutamine, short-chain fatty acids, and fish oil may offer therapeutic benefits.

Conclusions:

  • Effective nutritional management is essential for patients with chronic inflammatory bowel diseases.
  • Evidence supports the use of enteral and parenteral nutrition, alongside specific supplements, to address malnutrition in IBD.
  • Further research into alternative nutritional therapies may yield additional benefits for IBD patients.