[Topical preparations for burns and their evaluation]

Area of Science:

• Pharmaceutical Sciences
• Dermatology
• Materials Science

Context:

• Developing effective topical hydrocream formulations for dermal burn treatment presents formulation challenges.
• Evaluating various cream bases with specific emulsifiers and silicone oils is crucial for optimizing drug delivery.
• Incorporating active pharmaceutical ingredients like local anesthetics and antimicrobials requires understanding their interaction with the base.

Purpose:

• To assess the suitability of seven hydrocream bases for topical dermal burn preparations.
• To investigate the influence of emulsifiers (Emulgator E 2155, Polysorbate 80) and silicone oils on drug release.
• To analyze the impact of carbizocaine, lidocaine, chlorohexidine, and glucan on cream rheology and drying properties.

Summary:

• Seven hydrocream bases were evaluated for dermal burn treatment, incorporating carbizocaine, lidocaine, chlorohexidine, and glucan.
• Liberation tests showed enhanced release of lidocaine and chlorohexidine in the presence of silicone oil, while carbizocaine release was unaffected.
• No interaction was observed between chlorohexidine and carbizocaine. Drug addition significantly altered the rheological properties and drying characteristics of the cream bases.

Impact:

• Provides insights into optimizing hydrocream formulations for enhanced drug delivery in dermal burn therapy.
• Highlights the role of silicone oils in modulating the release kinetics of specific active ingredients.
• Offers data on the physicochemical properties of cream bases, aiding in the selection of suitable formulations for dermatological applications.