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Urinary endothelin-1 in children with acute renal failure of tubular origin

Y K Tsau1, W S Tsai, C H Chen

  • 1Department of Pediatrics, National Taiwan University Hospital, Taipei.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|July 3, 1998
PubMed

Insights

Urinary endothelin-1 (ET-1) levels change with age in children and are altered in acute renal failure (ARF). Renal production, not filtration, appears to be the primary source of urinary ET-1 in humans.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Biochemistry

Background:

  • Endothelin-1 (ET-1) is a potent vasoconstrictor with implications in renal function.
  • Urinary ET-1 excretion patterns and its origin in children, particularly during acute renal failure (ARF), are not well understood.

Purpose of the Study:

  • To characterize developmental changes in urinary ET-1 concentrations in healthy children.
  • To investigate the changes in urinary and plasma ET-1 in children with ARF.
  • To explore the source of urinary ET-1 in humans.

Main Methods:

  • Measured urinary endothelin-1 to creatinine ratio (ET-1/Cr) in 70 healthy children and 12 children with ARF.
  • Correlated urinary ET-1/Cr with daily urinary ET-1 and plasma ET-1 levels.
  • Monitored ET-1 levels during the course of ARF relative to serum creatinine peaks.

Main Results:

  • Urinary ET-1/Cr was highest in infancy among healthy children.
  • Children with ARF showed elevated plasma ET-1 and a positive correlation between urinary ET-1/Cr and total urinary ET-1.
  • Urinary ET-1/Cr decreased during peak serum creatinine in ARF, while plasma ET-1 declined post-peak.

Conclusions:

  • Urinary ET-1 concentrations exhibit developmental changes in children.
  • ARF alters both plasma and urinary ET-1 levels.
  • Results suggest renal production is the main source of urinary ET-1, rather than glomerular filtration.

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