[Paraneoplastic autoimmune neurologic syndromes]

Paraneoplastic neurologic syndromes are group of distant nonmetastatic neurologic manifestations of malignant diseases. In last few decades a major advance in understanding their etiology and pathogenesis has been achieved. Larger series of patients have been reported allowing more detailed clinical research of particular syndromes. To practicing physician they can be a first clinical sign in diagnosing a neoplasm. In these conditions immunologists can test new theories in tumor immunology and autoimmunity. To the oncologists they can serve as a model in development of new modalities of treating malignant tumors. Neurologic syndromes that can be explained as autoimmune reactions initiated by the development of malignancy are presented in this paper.