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Related Experiment Videos

Dancing eye syndrome and hyperphosphatasemia

D E Hasaerts1, F K Gorus, L J De Meirleir

  • 1Department of Pediatrics, Academisch Ziekenhuis-Kinderen Vrije Universiteit Brussel, Brussels, Belgium.

Pediatric Neurology
|July 3, 1998
PubMed
Summary
This summary is machine-generated.

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This study reports a rare case of dancing eye syndrome in an infant, linked with high levels of alkaline phosphatase. Steroid therapy improved symptoms, suggesting an autoimmune cause for this unique presentation.

Area of Science:

  • Pediatric Neurology
  • Clinical Biochemistry
  • Immunology

Background:

  • Dancing eye syndrome (DES) is a rare neurological disorder characterized by involuntary eye movements.
  • Elevated serum alkaline phosphatase (SAP) is typically associated with liver or bone conditions, or certain malignancies.

Observation:

  • An 11-month-old boy presented with recurrent episodes of dancing eye syndrome.
  • During these episodes, significant elevation of serum alkaline phosphatase (SAP), lactate dehydrogenase (LDH), and aminotransferase activities was observed.
  • SAP levels rose up to four times the upper limit of normal, normalizing with clinical improvement under steroid treatment.

Findings:

  • No evidence of primary liver or bone pathology was found.
  • No neural crest tumor was detected.

Related Experiment Videos

  • This is the first reported association between dancing eye syndrome and hyperphosphatasemia (elevated SAP).

    • Implications:

    • The normalization of SAP and clinical symptoms with steroid therapy suggests an autoimmune etiology for this combined presentation.
    • This case expands the understanding of potential systemic manifestations of dancing eye syndrome.
    • Further research into autoimmune mechanisms underlying DES is warranted.