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A case of glomeruloid hemangioma associated with multicentric Castleman's disease
1Department of Dermatology, Seoul National University College of Medicine, South Korea.
Insights
Glomeruloid hemangioma, a rare vascular tumor, is often linked to POEMS syndrome and multicentric Castleman
Area of Science:
- Vascular Oncology
- Dermatopathology
- Oncogenesis
Background:
- Glomeruloid hemangioma (GH) is a rare vascular neoplasm.
- GH shares histopathological similarities with renal glomeruli.
- Previous cases associated GH with POEMS syndrome and multicentric Castleman's disease (MCD).
Observation:
- A 44-year-old Korean woman presented with GH.
- Her condition was associated with MCD and POEMS syndrome features.
- Initial biopsy showed an unclassifiable immature vascular tumor; a second revealed GH.
Findings:
- This case supports the hypothesis that vascular proliferations in POEMS disease are reactive.
- These proliferations may arise due to angiogenic stimuli.
- GH represents one end of a histopathological spectrum of reactive vascular growths.
Implications:
- GH may be a reactive vascular proliferation in POEMS disease.
- The findings suggest a spectrum of vascular tumors in POEMS syndrome.
- Understanding this spectrum aids in diagnosing and managing associated conditions.
Abstract:
Glomeruloid hemangioma is a term that was coined J.K.C. Chan and colleagues in 1990 because the condition is histopathologically similar to renal glomeruli. In the three cases described to date, there have been signs of POEMS syndrome of multicentric Castleman's disease. We present the case of a 44-year-old Korean woman who developed glomeruloid hemangioma in association with multicentric Castleman's disease and some features of POEMS syndrome. It is interesting that in this patient, the first biopsy specimen revealed an immature vascular tumor that could not be precisely classified and the second indicated glomeruloid hemangioma. The present case may lend support to the suggestion that in POEMS disease, some types of vascular proliferations develop in response to angiogenic stimuli that show a spectrum of histopathologic features, and glomeruloid hemangioma is one of the reactive vascular proliferations. We believe that the primitive vascular tumor seen in the first biopsy specimen may be the most immature stage of this spectrum.