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Related Experiment Videos

Sugar polymers in rats and man

H L Dhar, T H Hanahoe, G B West

    International Archives of Allergy and Applied Immunology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    A glucan contaminant found in sugars caused skin reactions in humans and rats. This finding highlights the potential for glucan contaminants to elicit inflammatory responses in vivo.

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    Area of Science:

    • Immunology
    • Dermatology
    • Food Science

    Background:

    • Glucan contaminants can be present in processed sugar products.
    • Understanding the biological activity of these contaminants is important for safety assessments.

    Purpose of the Study:

    • To investigate the skin reactivity of a glucan contaminant from invert sugar and crude cane sugar.

    Main Methods:

    • Intracutaneous injections of glucan into human skin.
    • Intradermal injections of glucan into dextran-sensitive and dextran-resistant rats.

    Main Results:

    • Glucan injections in humans caused localized wheal and erythema (skin swelling and redness).
    • The glucan demonstrated biological activity in both types of rats upon intradermal administration.

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    Conclusions:

    • The tested glucan contaminant possesses inflammatory properties.
    • Further research is warranted to assess the implications of glucan contaminants in food products.