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Fast pathway ablation in patients with common atrioventricular nodal reentrant tachycardia and prolonged PR interval
C Reithmann1, E Hoffmann, A Grünewald
1Medizinische Klinik I, Klinikum Grosshadern, Universität München, Germany.
Insights
Selective fast pathway ablation is safe and effective for atrioventricular nodal reentrant tachycardia (AVNRT) patients with prolonged PR intervals. This procedure successfully terminated AVNRT without causing significant atrioventricular block during follow-up.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Atrioventricular nodal reentrant tachycardia (AVNRT) is a common supraventricular tachycardia.
- Patients with AVNRT and a prolonged PR interval during sinus rhythm may have an increased risk of complete atrioventricular block.
- Selective fast pathway ablation offers a potential treatment strategy for these patients.
Purpose of the Study:
- To evaluate the safety and efficacy of selective fast pathway ablation in patients with AVNRT and a prolonged PR interval.
- To assess the risk of atrioventricular block during and after the ablation procedure.
Main Methods:
- Localization of earliest retrograde atrial activation during AVNRT and right ventricular stimulation.
- Radiofrequency catheter ablation of the fast pathway in five patients.
- Assessment of ventriculo-atrial block and non-inducibility of AVNRT.
- Monitoring of PR and atrio-His intervals.
- Follow-up for symptoms and atrioventricular block.
Main Results:
- Successful ablation achieved complete ventriculo-atrial block in four patients and marked prolongation in one.
- Non-inducibility of AVNRT was achieved in all patients.
- No second- or third-degree atrioventricular block occurred during the procedure.
- PR and atrio-His intervals showed significant prolongation post-ablation.
- No AVNRT recurrence or AV block was observed during a mean follow-up of 19 months.
Conclusions:
- Selective fast pathway ablation appears to be a safe and effective treatment for AVNRT in patients with a prolonged PR interval.
- The procedure does not significantly increase the risk of atrioventricular block in this patient population.
Aims:
This study aimed to clarify the safety and efficacy of selective fast pathway ablation in patients with atrioventricular nodal reentrant tachycardia and a prolonged PR interval during sinus rhythm. Such patients have been reported to have an increased incidence of complete atrioventricular block.
Methods And Results:
In this study, the earliest retrograde atrial activation during atrioventricular nodal reentrant tachycardia and right ventricular stimulation was localized. Fast pathway ablation was then performed in five patients with the common form of atrioventricular nodal reentrant tachycardia and a prolonged PR interval. Three of the five patients had almost incessant atrioventricular nodal reentrant tachycardia. Radiofrequency catheter ablation induced a complete ventriculo-atrial block during right ventricular stimulation in four patients and a marked prolongation of ventriculo-atrial conduction during right ventricular stimulation in one. Non-inducibility of common atrioventricular nodal reentrant tachycardia with and without isoproterenol was achieved in all five patients. The PR interval increased from 254 +/- 53 ms to 276 +/- 48 ms and the atrio-His interval from 172 +/- 46 ms to 192 +/- 45 ms. Second- or third-degree atrioventricular block did not occur during the ablation procedure. During the followup of 19 +/- 20 months none of the patients developed symptoms suggestive of atrioventricular nodal reentrant tachycardia or evidence of second- or third-degree atrioventricular block.
Conclusion:
These data suggest that atrioventricular node (retrograde) fast pathway ablation can apparently be safely performed in patients with common atrioventricular nodal reentrant tachycardia and a prolonged PR interval during sinus rhythm.
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