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Related Experiment Videos

Structure and functions of CD23

J Y Bonnefoy1, S Lecoanet-Henchoz, J F Gauchat

  • 1Geneva Biomedical Research Institute, Immunology Department, Geneva, Switzerland.

International Reviews of Immunology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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CD23, a unique IgE receptor, functions beyond IgE binding. This molecule interacts with other cell surface proteins, highlighting its role as an adhesion molecule in cell-cell interactions.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • CD23 is a low-affinity receptor for IgE (Fc epsilon RII), distinct from the immunoglobulin gene superfamily.
  • Initially identified as an IgE receptor, CD23 also functions as a B-cell activation antigen and cell surface marker.
  • Soluble forms of CD23 (sCD23) are released, retaining IgE-binding capabilities and exhibiting additional non-IgE related functions.

Purpose of the Study:

  • To review recent data on the structure and function of CD23.
  • To explore the multifaceted roles of CD23 beyond its IgE receptor function.
  • To discuss the biological activities of human CD23.

Main Methods:

  • Literature review of recent data on CD23.
  • Analysis of CD23's molecular structure and homology to C-type lectins.

Related Experiment Videos

  • Examination of CD23 interactions with other cell surface molecules (CD21, CD11b, CD11c).

    • Main Results:

    • CD23 exhibits homology to Ca(2+)-dependent (C-type) animal lectins, suggesting non-IgE ligands.
    • Soluble CD23 fragments possess functions independent of IgE binding.
    • CD23 interacts with CD21, CD11b, and CD11c, indicating its role as an adhesion molecule.

    Conclusions:

    • CD23 functions as both a low-affinity IgE receptor and an adhesion molecule involved in cell-cell interactions.
    • The diverse functions of CD23 extend beyond IgE binding, involving interactions with various cell surface proteins.
    • Further research into CD23's biological activities is warranted.