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Hormonal therapy and cholelithiasis

G N Weiss, E B Weiss

    International Surgery
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Hormonal birth control may increase the risk of gallstones (cholelithiasis) in younger women by affecting gallbladder function. Early detection and surgery are recommended for those on hormonal therapy.

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    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Surgical Oncology

    Background:

    • Cholelithiasis (gallstones) incidence is rising in younger women.
    • While biochemical changes and mechanical obstruction are known causes, the impact of female hormones on gallbladder function is less understood.
    • Estrogen-progesterone elevation during pregnancy is linked to hypercholesterolemia, a known risk factor.

    Purpose of the Study:

    • To alert abdominal surgeons to a new factor contributing to cholelithiasis in young women.
    • To investigate the association between hormonal medication and the incidence of cholelithiasis.
    • To highlight the role of hormonal therapy in the development of gallbladder disease.

    Main Methods:

    • A retrospective survey of 1346 cholecystic operations performed between 1969 and 1973.

    Related Experiment Videos

  • Comparison of age at operation between young women (<40 years) on hormonal medication versus a control group not on hormonal therapy.

    • Main Results:

    • A higher incidence of cholelithiasis was observed in women, as expected.
    • Women under 40 using hormonal medication underwent surgery at a younger age compared to those not on hormonal therapy.
    • Hormonal therapy appears to predispose women to gallbladder disease.

    Conclusions:

    • Female hormones can cause gallbladder sluggishness, leading to functional obstruction and predisposing to cholelithiasis.
    • The incidence of gallbladder disease in young women using hormonal therapy is expected to increase.
    • Cholelithiasis should be suspected in young females using birth control medication; early diagnosis and surgical intervention are advised.