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Related Experiment Videos

Propagating waves control Dictyostelium discoideum morphogenesis

D Dormann1, B Vasiev, C J Weijer

  • 1Department of Anatomy and Physiology, University of Dundee, UK.

Biophysical Chemistry
|July 4, 1998
PubMed
Summary
This summary is machine-generated.

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Waves guide slime mold development. Propagating waves organize Dictyostelium morphogenesis, transforming cell movement and sorting to create complex structures like slugs and fruiting bodies.

Area of Science:

  • Cellular and developmental biology
  • Biophysics
  • Mathematical biology

Background:

  • Dictyostelium morphogenesis involves coordinated cell movement, differentiation, and sorting.
  • Cellular aggregation is driven by waves of the chemoattractant cyclic AMP (cAMP).
  • The role of waves in organizing multicellular structures beyond initial aggregation was unclear.

Purpose of the Study:

  • To investigate the role of propagating waves in organizing Dictyostelium mounds.
  • To understand how wave geometry evolves during mound formation.
  • To model the interplay between cell sorting and wave dynamics in slug morphogenesis.

Main Methods:

  • Observation of wave patterns in Dictyostelium mounds.
  • Mathematical modeling of cell sorting based on differential speed and excitability.

Related Experiment Videos

  • Analysis of wave geometry transitions (spirals to rings).

    • Main Results:

    • Dictyostelium mounds are organized by propagating waves, not just during aggregation.
    • Wave patterns transition from spirals to multi-armed spirals and transient rings within mounds.
    • Cell sorting, influenced by cell-specific movement and excitability, feeds back to create twisted scroll waves in the slug.

    Conclusions:

    • Morphogenesis in Dictyostelium is fundamentally directed by wave propagation.
    • Wave dynamics play a crucial role in organizing cell sorting and pattern formation.
    • This wave-based mechanism explains the development of complex multicellular structures from single cells.