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Updated: Aug 16, 2026

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
Published on: October 6, 2019
Self-organizing molecular networks
P Stange1, D Zanette, A Mikhailov
1Abteilung Physikalische Chemie, Fritz-Haber-Institut der Max-Planck-Gesellschaft, Berlin, Germany.
Abstract:
Strong diffusional mixing and short delivery times typical for micrometer and sub-micrometer reaction volumes lead to a special situation where the turnover times of individual enzyme molecules become the largest characteristic time scale of the chemical kinetics. Under these conditions, populations of cross-regulating allosteric enzymes form molecular networks that exhibit various kinds of self-organized coherent collective dynamics.
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