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07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Spectrum of AIDS-associated malignant disorders
J J Goedert1, T R Coté, P Virgo
1Viral Epidemiology Branch, National Cancer Institute, Rockville, MD, USA. jg8s@nih.gov
Lancet (London, England)
|July 4, 1998
Summary
People with AIDS have a significantly increased risk of developing Hodgkin's disease, multiple myeloma, brain cancer, and seminoma. These findings suggest a link between acquired immunodeficiency syndrome (AIDS) and certain cancers beyond Kaposi's sarcoma and non-Hodgkin lymphoma.
Area of Science:
- Epidemiology
- Immunology
- Oncology
Background:
- Acquired immunodeficiency syndrome (AIDS) is associated with certain cancers.
- Clarifying the full spectrum of AIDS-related cancers is crucial for patient care and public health.
Purpose of the Study:
- To identify specific cancer types that result from AIDS.
- To compare cancer incidence in people with AIDS versus the general population.
Main Methods:
- Utilized population-based cancer and AIDS registries in the USA and Puerto Rico.
- Employed a probabilistic matching algorithm on names, birth dates, and social security numbers for 98,336 people with AIDS and 1,125,098 cancer patients.
- Defined AIDS-related cancers based on significantly increased incidence post-AIDS and increasing prevalence around the AIDS diagnosis period.
Main Results:
- Confirmed significantly elevated rates of Kaposi's sarcoma (310-fold) and non-Hodgkin lymphoma (113-fold) in people with AIDS.
- Identified significantly increased incidence and prevalence for Hodgkin's disease (7.6-fold), multiple myeloma (4.5-fold), brain cancer (3.5-fold), and seminoma (2.9-fold).
- Observed a 1.9-fold increased incidence for other cancers, with specific malignant disorders showing significant increases.
Conclusions:
- AIDS is associated with a significantly increased risk for Hodgkin's disease, multiple myeloma, brain cancer, and seminoma.
- Immunological deficiency in controlling viral infections may contribute to the development of these AIDS-related malignant diseases.
- Shared risk factors and screening complexities warrant careful interpretation of findings.
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