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Related Experiment Videos

Evidence for multiclonality in multicentric Kaposi's sarcoma

P S Gill1, Y C Tsai, A P Rao

  • 1Department of Medicine, Norris Comprehensive Cancer Center, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.

Proceedings of the National Academy of Sciences of the United States of America
|July 8, 1998
PubMed
Summary
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Kaposi

Area of Science:

  • Oncology
  • Virology
  • Genetics

Background:

  • Kaposi's sarcoma (KS) is the most common tumor in HIV-1 infection.
  • KS presents as multifocal mucocutaneous disease, sometimes spreading to visceral organs.
  • The neoplastic nature of KS has been debated due to its multifocality and spontaneous regression.

Purpose of the Study:

  • To determine if Kaposi's sarcoma lesions are clonal, indicating neoplasia.
  • To investigate if multifocal KS lesions originate from a common progenitor or independent cells.

Main Methods:

  • Analyzed X-chromosome inactivation patterns of the human androgen receptor gene in KS tumor biopsies from women.
  • Microdissected specimens to minimize normal cell contamination.
  • Examined 24 biopsies from 12 patients (10 HIV-seropositive, 2 HIV-seronegative).

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Main Results:

  • Five cases showed individual KS lesions were clonal.
  • Two cases demonstrated distinct clonal origins for multiple KS lesions within the same patient.
  • Seven cases exhibited polyclonal inactivation patterns; two had mixed clonal and polyclonal areas.

Conclusions:

  • Kaposi's sarcoma can arise as a clonal neoplasm.
  • Multiple KS lesions in a single patient may originate independently.
  • Polyclonal patterns might indicate a premalignant stage or require further investigation.