Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reduction and integration in understanding the heart

D Noble1

  • 1Department of Physiology, University of Oxford, UK.

Novartis Foundation Symposium
|July 8, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identifying markers of cachexia and nutritional deficit on radical radiotherapy outcomes in lung and head and neck cancer.

Current opinion in supportive and palliative care·2026
Same author

Prognostic Implications of HPV Cell-Free DNA Serial Testing During Follow-Up of p16 Positive Oropharyngeal Squamous Cell Carcinoma After Curative-Intent Treatment.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

Effects of Natura 2000 on nontarget bird and butterfly species based on citizen science data.

Conservation biology : the journal of the Society for Conservation Biology·2019
Same author

Negative relationships between species richness and temporal variability are common but weak in natural systems.

Ecology·2018
Same author

Bridging Systems Medicine and Patient Needs.

CPT: pharmacometrics & systems pharmacology·2015
Same author

Progress in understanding electro-mechanical signalling in the myometrium.

Acta physiologica (Oxford, England)·2014

Understanding complex heart function requires an integrative approach beyond cellular studies. The sodium-calcium exchanger

Area of Science:

  • Cardiology
  • Computational Biology
  • Physiology

Background:

  • Cardiac function relies on complex interactions of ion transporters and metabolic states.
  • Recent advances focus on cellular and molecular levels, neglecting integrative physiological understanding.
  • Lack of integrative understanding hinders effective treatment of cardiac diseases, particularly arrhythmias.

Purpose of the Study:

  • To highlight the limitations of reductive approaches in cardiac research.
  • To emphasize the need for an integrative understanding of heart function at cellular and whole-organ levels.
  • To analyze the role of the sodium-calcium exchanger in normal and pathological heart rhythms.

Main Methods:

  • Analysis of normal and abnormal heart rhythms.

Related Experiment Videos

  • Focus on the sodium-calcium exchanger's role in calcium balance and arrhythmias.
  • Computational modeling at an integrative level.

    • Main Results:

    • Reductive approaches have limits in explaining complex cardiac physiology.
    • The sodium-calcium exchanger is crucial for cardiac calcium balance and arrhythmogenesis.
    • Integrative computational analysis reveals counterintuitive results in cardiac function.

    Conclusions:

    • An integrative approach is essential for understanding cardiac physiology and treating heart disease.
    • The sodium-calcium exchanger's complex role necessitates systems-level analysis.
    • Future cardiac research must bridge cellular mechanisms with whole-organ function for therapeutic success.