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In vivo microdialysis study of (+/-)-kavain on veratridine-induced glutamate release
B Ferger1, G Boonen, H Häberlein
1Institute of Pharmacology and Toxicology, Faculty of Pharmacy, Philipps-University of Marburg, Germany. ferger@mailer.uni-marburg.de
Abstract:
This is the first microdialysis study to address the effects of (+/-)-kavain on veratridine-induced glutamate release in freely moving rats. (+/-)-Kavain (100 mg/kg, p.o.) significantly reduced veratridine-induced glutamate release compared with that of vehicle-treated controls. Maximum extracellular glutamate levels were obtained 20-40 min after veratridine stimulation (500 microM, added to the perfusate). In the control group the increase was 301% and in the (+/-)-kavain group the increase was significantly reduced to 219% (the basal value was 100%). These results demonstrate that (+/-)-kavain reduces veratridine-induced glutamate release in vivo, which confirms previous in vitro data.