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A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl
T Kimura1, H Kaburaki, T Tsujino
1Research and Development Division, Hokuriku Seiyaku Co., Ltd, Katsuyama, Fukui, Japan. tki@land.hokuriku.or.jp
FEBS Letters
|July 8, 1998
Abstract:
Thrombopoietin (TPO) is a cytokine which plays a central role in megakaryopoiesis and platelet production by binding to its cell surface receptor, termed c-Mpl. In the present study, two benzodiazepinones that compete with the binding of TPO to the extracellular region of c-Mpl were identified, and one of them stimulated the proliferation of a human TPO-dependent megakaryocytic cell line, UT-7/TPO. It stimulated the activation of signal transducer and activator of transcription 5 in UT-7/TPO cells. These results suggest that a non-peptide compound can mimic the effect of TPO via c-Mpl.