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NMR temperature measurements using a paramagnetic lanthanide complex

C S Zuo1, K R Metz, Y Sun

  • 1Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|July 9, 1998
PubMed
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Nuclear magnetic resonance (NMR) thermometry is improved using the thulium 1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) complex (TmDOTP5-). This paramagnetic agent offers high accuracy and resolution for in vivo temperature measurements.

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Traditional NMR thermometry faces limitations in thermal resolution due to weak temperature dependence of chemical shifts in diamagnetic molecules.
  • Paramagnetic centers significantly enhance the temperature sensitivity of nuclear spin chemical shifts.

Purpose of the Study:

  • To evaluate the thulium 1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetrakis(methylene phosphonate) complex (TmDOTP5-) as a sensitive agent for NMR thermometry.
  • To investigate the influence of temperature, pH, and Ca2+ concentration on TmDOTP5- chemical shifts for potential in vivo applications.

Main Methods:

  • Studied the chemical shifts of 1H and 31P nuclei in the TmDOTP5- complex across varying temperatures, pH levels, and Ca2+ concentrations.
  • Developed a novel technique for simultaneous temperature and pH monitoring using multiple TmDOTP5- spectral lines.

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Main Results:

  • Demonstrated that 1H and 31P chemical shifts in TmDOTP5- exhibit high sensitivity to temperature variations.
  • Confirmed the potential of TmDOTP5- for accurate and high-resolution NMR thermometry.
  • Showcased a new method for simultaneous in vivo temperature and pH measurements.

Conclusions:

  • TmDOTP5- is a highly effective agent for improving NMR thermometry accuracy and resolution.
  • The developed technique allows for simultaneous monitoring of temperature and pH, crucial for physiological studies.
  • This advancement holds promise for enhanced in vivo diagnostics and research.