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Acute isoniazid poisoning: presenting as seizure
1Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.
Summary
Isoniazid poisoning can cause status epilepticus in young females. Prompt treatment with pyridoxine (vitamin B6) is life-saving for isoniazid toxicity.
Area of Science:
- Neurology
- Toxicology
- Emergency Medicine
Background:
- Isoniazid is a common antitubercular drug.
- Isoniazid overdose can lead to severe neurological complications.
- Status epilepticus is a medical emergency characterized by prolonged seizures.
Observation:
- A young female presented with status epilepticus.
- The patient had a history of isoniazid poisoning.
- Seizures were refractory to standard antiepileptic drugs.
Findings:
- Pyridoxine (vitamin B6) administration was initiated.
- Pyridoxine effectively controlled the seizures.
- The patient's neurological status improved significantly.
Implications:
- Early recognition of isoniazid-induced seizures is crucial.
- Pyridoxine is a highly effective antidote for isoniazid poisoning.
- This case highlights the importance of prompt pyridoxine treatment in managing isoniazid toxicity.