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Clinical regeneration with guided tissue barriers

G H Evans¹, R A Yukna, K M Cambre

¹Louisiana State University, School of Dentistry, New Orleans 70119, USA.

Current Opinion in Periodontology

|January 1, 1997

Summary

Polylactic acid/polyglactin (PLA/PGA) barriers showed the best clinical results for periodontal regeneration in infrabony defects and furcations. However, no significant differences were found among various barrier types.

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Area of Science:

Periodontology
Regenerative Dentistry

Background:

Guided tissue regeneration (GTR) utilizes barrier membranes to promote periodontal regeneration.
Effectiveness of GTR varies depending on defect type and barrier material.

Purpose of the Study:

To review and meta-analyze clinical outcomes of guided tissue barriers in treating periodontal infrabony defects and furcations.
To compare the efficacy of different barrier materials for periodontal regeneration.

Main Methods:

Systematic review of periodontal literature.
Meta-analysis of clinical data, calculating weighted means and confidence intervals.
Evaluation of pocket reduction, probing attachment level gain, and furcation closure rates.

Main Results:

Polylactic acid/polyglactin (PLA/PGA) barriers demonstrated the most favorable outcomes for infrabony defects, with mean pocket reduction of 5.3 mm and mean attachment gain of 4.7 mm.
Complete furcation closure was infrequent (7-19%) with GTR barriers.
PLA/PGA barriers yielded the best clinical results for both defect types, though statistical significance was not achieved across different barrier types.

Conclusions:

PLA/PGA barriers appear most effective for periodontal regeneration in infrabony defects and furcations.
While PLA/PGA barriers show promising results, further research is needed to establish statistically significant differences among barrier types.
Guided tissue regeneration with barriers offers a viable treatment option for periodontal defects, with varying degrees of success in furcation closure.

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