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The effect of age and temperature on mdx muscle fatigue
M A Wineinger1, S A Walsh, R T Abresch
1Department of Physical Medicine and Rehabilitation, University of California School of Medicine, Davis 95616, USA.
Muscle & Nerve
|July 9, 1998
Abstract:
We have studied the in vitro contractile and fatigue characteristics of extensor digitorum longus (EDL) muscles from 8- and 62-week-old dystrophin-deficient (mdx) and control mice at 20 degrees C and 35 degrees C. There were no differences in fatigability at 20 degrees C, but at 35 degrees C the dystrophin-deficient muscles demonstrated increased fatigability compared to controls, with the older mice exhibiting the greatest fatigue. These results suggest a temperature-related mechanism of myofibrillar fatigue in dystrophin-deficient EDL muscles.