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Intratympanic gentamicin in Meniere's disease
S Kaasinen1, I Pyykkö, H Ishizaki
1Department of Otolaryngology, University Hospital of Helsinki, Finland.
Acta Oto-Laryngologica
|July 9, 1998
Summary
Intratympanic gentamicin injections effectively treat Meniere
Area of Science:
- Otolaryngology
- Neurology
Background:
- Meniere's disease causes debilitating vertigo, tinnitus, and hearing loss.
- Intractable Meniere's disease often requires advanced treatment strategies.
Purpose of the Study:
- To evaluate the efficacy and safety of transtympanic gentamicin injections for intractable Meniere's disease.
- To identify factors predicting treatment outcomes.
Main Methods:
- Ninety-three patients received 1-4 transtympanic gentamicin injections.
- Patients were followed for 2 years with regular testing.
Main Results:
- 81% achieved resolution of rotatory vertigo; 60% were cured of Tumarkin attacks.
- Hearing level worsened significantly (mean 59.1 to 67.9 dB HL), with 10 ears deafened.
- Poor outcomes correlated with Tumarkin attacks, vertigo severity, and gait disorders.
Conclusions:
- Transtympanic gentamicin is a relatively safe and effective treatment for Meniere's disease.
- Initial treatment with two injections, with retreatment if needed, is recommended.