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Related Experiment Videos

The changing face of mesenteric infarction

T S Newman1, T H Magnuson, S A Ahrendt

  • 1Department of Surgery, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224, USA.

The American Surgeon
|July 9, 1998
PubMed
Summary

Intestinal infarction is a severe condition with a 50% mortality rate. Elevated serum lactate levels are the primary predictor of death, highlighting the need for early diagnosis and intervention in at-risk patients.

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Area of Science:

  • Gastroenterology
  • Surgical Pathology

Background:

  • Intestinal infarction is a critical condition with high mortality despite advances in care.
  • The evolving causes of intestinal infarction require updated examination.

Purpose of the Study:

  • To investigate recent changes in the etiology and outcomes of intestinal infarction.
  • To identify predictors of mortality in patients with intestinal infarction.

Main Methods:

  • Retrospective review of 121 consecutive patients diagnosed with intestinal infarction over a 6-year period.
  • Analysis of patient demographics, clinical presentation, treatment, and outcomes.
  • Statistical analysis to identify significant predictors of mortality.

Main Results:

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  • Overall mortality was 50% in 98 operated patients.
  • Elevated serum lactate at diagnosis was the sole significant predictor of mortality.
  • Nonocclusive mesenteric infarction was the most frequent cause, often occurring in hospitalized patients.
  • 39% of cases were due to non-obstructive causes, frequently in patients already hospitalized for other conditions.

    • Conclusions:

    • Nonocclusive mesenteric infarction is increasingly prevalent, linked to systemic illness in hospitalized patients.
    • Prompt evaluation for mesenteric ischemia is crucial in critically ill or postoperative patients with unexplained acidosis.
    • Intestinal infarction may be a manifestation of multisystem organ failure.