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Tinea capitis: fluconazole in Trichophyton tonsurans infection
M G Mercurio1, R A Silverman, B E Elewski
1University of Rochester School of Medicine and Dentistry, New York, USA.
Pediatric Dermatology
|July 9, 1998
Summary
Tinea capitis, a common childhood fungal infection, can be effectively treated with fluconazole. This antifungal offers a well-tolerated, liquid option for pediatric patients, expanding treatment choices beyond griseofulvin.
Area of Science:
- Dermatology
- Pediatric Mycology
- Infectious Diseases
Background:
- Tinea capitis is the most prevalent dermatophyte infection in children.
- Griseofulvin has been the standard treatment for Tinea capitis for over 40 years.
- Emerging antifungal agents offer alternatives to griseofulvin, allowing for tailored pediatric treatment.
Observation:
- Fluconazole, an azole antifungal, is available in a palatable liquid formulation suitable for children.
- Fluconazole possesses a favorable safety profile and is approved for pediatric use in the US.
- This study details five pediatric cases of Tinea capitis successfully managed with fluconazole.
Findings:
- Fluconazole demonstrated efficacy in treating Tinea capitis across five pediatric patients.
- The liquid formulation of fluconazole was well-tolerated by the pediatric subjects.
- Successful treatment outcomes were achieved without reported adverse events.
Implications:
- Fluconazole represents a viable and effective alternative therapeutic option for pediatric Tinea capitis.
- The drug's formulation and safety profile make it particularly suitable for pediatric populations.
- Expanding treatment guidelines to include fluconazole may improve Tinea capitis management in children.