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Molecular cloning of a gene encoding phospholipase D from the pathogenic and dimorphic fungus, Candida albicans
1Department of Dermatology, Gifu University School of Medicine, Tsukasamachi-40, Gifu 500-8076, Japan.
Biochimica Et Biophysica Acta
|July 10, 1998
Abstract:
A phospholipase D gene (CaPLD) has been cloned from the Candida albicans genomic DNA library. The CaPLD is a member of a highly conserved gene family of PLD and has the highest homology to Saccharomyces cerevisiae PLD (SPO14) with an overall homology of 42%. Phylogenetic analysis indicated that fungus PLDs including CaPLD composed one of the three clusters of PLD genes.