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[Pyelocaliceal urothelial carcinoma associated with pelvis lithiasis]
M Medina Pérez1, I Valpuesta Fernández, J Valero Puerta
1Servicio de Anatomía Patológica, Hospital de La Merced, Sevilla, España.
Objective:
Epithelial neoplasms of the upper collecting system account for less than 5 percent of all urothelial tumors and they are not histologically unlike those of the bladder. We report a case of pelviocaliceal urothelial carcinoma associated with a calculus in the renal pelvis.
Methods:
A 75-year-old man who presented with hematuria, fever and flank pain is described. The US and CT findings disclosed a calculus in the left renal pelvis and hydronephrosis nephrectomy was performed.
Results:
The pathological analysis revealed a pelviocaliceal urothelial carcinoma on an underlying stone and overexpression of the p53 protein.
Conclusion:
Diagnostic imaging techniques may fail to detect tumors of the renal pelvis with a large underlying stone. The overexpression of the p53 protein may be involved in the malignant transformation of the urothelial cells.