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[Hematuria, dysuria, pollakiuria and general malaise, in a patient treated with BCG instillations]
M Medina Pérez1, M Sánchez González, A Espino Montoro
1Servicio de Anatomía Patológica, Hospital de la Merced, Sevilla, España.
Objective:
To report a case of granulomatous cystitis in a patient receiving bacillus Calmette-Guerin intravesical therapy for urothelial carcinoma in situ.
Methods:
A 58-year-old man undergoing BCG intravesical therapy for urothelial carcinoma in situ presented symptoms of intense cystitis. Cystoscopy was performed and several bladder cold biopsies were obtained.
Results:
Histopathological analysis demonstrated epithelioid granulomas.
Conclusion:
Cystitis arising from BCG therapy is defined as drug-induced or BCG-induced cystitis. Intense cystitis and malaise are a serious complication since it is not possible to distinguish patients with a simple uncomplicated local reaction from those who will develop progressive systemic infection. Cystoscopy and biopsy can be helpful in determining the nature of the condition and are recommended.