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Related Experiment Videos

Primary progressive semantic aphasia: a case study

A Kertesz1, W Davidson, P McCabe

  • 1Department of Clinical Neurological Sciences, University of Western Ontario, St. Joseph's Health Centre, Lawson Research Institute, London, Canada. kertesz@lri.stjosephs.london.on.ca

Journal of the International Neuropsychological Society : JINS
|July 10, 1998
PubMed
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This study details a patient with progressive semantic dementia, showing a frequency-dependent loss of object meaning. Despite severe anomia, preserved autobiographical memory suggests semantic memory fractionation.

Area of Science:

  • Neuroscience
  • Linguistics
  • Cognitive Psychology

Background:

  • Presents a longitudinal case study of a patient with progressive loss of object meaning.
  • Focuses on preserved phonology and syntax despite semantic deficits.

Observation:

  • Patient exhibits severe anomia and comprehension deficits across all modalities after 8 years.
  • Maintained conversational speech, social skills, and orientation throughout the study.
  • Demonstrated frequency-dependent loss of meaning across all object categories and stimulus modalities.

Findings:

  • Semantic memory shows fractionation, with relative preservation of visual categorization and language-based animal categorization.
  • Autobiographical and personal memories were relatively preserved compared to semantic memory.

Related Experiment Videos

  • Impaired central semantic processing evidenced by item consistency of loss and lack of semantic cuing.

    • Implications:

    • Neuroimaging revealed left temporal lobe atrophy, consistent with semantic dementia or transcortical sensory aphasia with visual agnosia.
    • Findings suggest Pick's disease as a potential diagnosis.
    • Highlights the complex nature of semantic memory and its selective impairment in neurodegenerative diseases.