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Some perspectives on modeling leukemia
1Department of Mathematics, Elmhurst College, IL 60126, USA. evansa@elmhurst.edu
Mathematical Biosciences
|July 10, 1998
Abstract:
A diffusion model of leukemia is presented. The space-occupying effects of leukemic cells during leukemic expansion is investigated. The analyses and simulations of the model suggest that acute leukemia is a state in which positions inhabited by colonies of normal cells are invaded by emerging colonies of abnormal cells. Normal cells are then driven to a state of extinction as leukemic cells evolve toward high and dominant steady state levels.