Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Radiobiological considerations for stereotactic irradiation]

N Shigematsu1, E Kunieda, T Kawada

  • 1Department of Radiology, Keio University School of Medicine.

Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica
|July 10, 1998
PubMed
Summary

Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) offer new options for brain tumors. Calculations guide the selection of SRS or SRT and optimal fractionated schedules for better patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of the Rash Appearance to Distinguish Cholinergic Urticaria Subtypes: A Retrospective Cohort Study.

American journal of clinical dermatology·2025
Same author

Improvement of redness and hyperkeratosis in a case of Nagashima-type palmoplantar keratosis during Tofacitinib treatment for ulcerative colitis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin.

Science immunology·2021
Same author

Linear and disseminated porokeratosis in one family showing identical and independent second hits in MVD among skin lesions, respectively: a proof-of-concept study.

The British journal of dermatology·2021
Same author

A case of type 1 segmental Darier disease showing widespread Blaschkoid skin lesions with p.P160L mutation in ATP2A2.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

An adult case of X-linked chronic granulomatous disease with skin ulcer on the nose and internal canthus.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020

Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Medical Physics

Background:

  • Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) are advanced radiation techniques for brain lesions.
  • Radiobiological factors require further evaluation for optimal application of SRS and SRT.

Purpose of the Study:

  • To calculate biologically effective doses for different target tissue categories.
  • To determine optimal indications for SRS and SRT, and suitable SRT schedules.

Main Methods:

  • Larson's classification of stereotactic irradiation (STI) targets was used.
  • Biologically effective doses were calculated for early- and late-responding tissues, considering tissue boundaries.

Main Results:

Related Experiment Videos

  • Theoretical recommendations: SRS for AVMs and benign tumors with clear margins; SRT for astrocytomas and metastases without clear boundaries.
  • Proposed SRT schedules: 49 Gy/7 fractions, 52 Gy/8 fractions, or 54.9 Gy/9 fractions within 2 weeks.

    • Conclusions:

    • Calculated doses provide a basis for SRS/SRT indications and SRT fractionation schedules.
    • Clinical application requires modification based on individual patient and tumor factors.