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Related Experiment Videos

[Remote effect in patients with thalamic stroke. A study using positron emission tomography]

Y Komaba1, S Kitamura, A Terashi

  • 1Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.

Nihon Ika Daigaku Zasshi
|July 10, 1998
PubMed
Summary

Thalamic stroke impacts distant brain regions, reducing cerebral blood flow (CBF) and oxygen metabolism (CMRO2). The left hemisphere shows stronger thalamus-temporal cortex connections, indicated by greater CMRO2 reduction in left thalamic stroke patients.

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Area of Science:

  • Neuroscience
  • Neurology
  • Cerebrovascular Diseases

Background:

  • The thalamus plays a crucial role in relaying sensory and motor signals to the cerebral cortex.
  • Thalamic stroke can lead to widespread functional deficits beyond the immediate lesion site.
  • Understanding the functional connectivity of the thalamus is essential for predicting stroke outcomes.

Purpose of the Study:

  • To investigate the functional relationship between the thalamus and other cortical regions following thalamic stroke.
  • To assess changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) in patients with thalamic stroke.
  • To explore hemispheric differences in thalamocortical functional connectivity.

Main Methods:

  • Positron emission tomography (PET) was used to measure regional CBF and CMRO2.

Related Experiment Videos

  • A steady-state inhalation technique with C15O2 and 15O2 was employed.
  • Twenty patients with thalamic stroke (infarction or hemorrhage) and 7 healthy controls were studied.

    • Main Results:

    • Thalamic stroke led to significant decreases in CMRO2 and CBF in regions distant from the lesion.
    • Left thalamic stroke patients showed decreased CMRO2 in ipsilateral temporal regions, suggesting stronger left-hemisphere thalamocortical connections.
    • Both left and right thalamic stroke groups exhibited reduced CMRO2 and CBF in various cortical and subcortical areas, including the cingulate, occipital, and cerebellar regions.

    Conclusions:

    • Thalamic lesions disrupt functional activity (CBF and CMRO2) in interconnected distant brain regions.
    • The findings suggest more intimate functional fiber connections between the thalamus and temporal cortex in the left hemisphere.
    • PET-based assessment of CBF and CMRO2 provides valuable insights into the remote effects of thalamic stroke.