Effect of guarana on exercise in normal and epinephrine-induced glycogenolytic mice

The tonic action of water Guarana extract, (Paullinia cupana MART.), was investigated in normal, exercised, and epinephrine-induced glycogenolytic mice. A water extract of Guarana (GW) (500 mg/kg) increased the blood glucose level (p < 0.001) and decreased the liver glycogen contents of mice 60 min after oral maltose administration (p < 0.05). GW also significantly suppressed exercise-induced hypoglycemia (60 min: p < 0.05). However, GW did not affect the blood glucose in epinephrine-induced glycogenolytic and exercise mice. These findings indicate that the suppressive mechanism of hypoglycemia might be due to the promotion of glycogen resolution.