The diurnal variation in blood pressure should be calculated from individually defined day and night times

The aim of this study was to compare the nocturnal fall in BP parameters calculated from individually defined periods of day and night to values computed from collectively fixed day/night definitions. Day and night periods were defined according to 3 different methods: (i) the individually defined time of getting up and going to bed obtained from participant diaries (MethodIND); (ii) the mean time of rising and retiring in the group (MethodMEAN); and (iii) a daytime period from 07.00-22.00 h as recommended by The Scientific Committee (Method722). The ambulatory BP was recorded every 30 min over 24 h. One hundred and eighty-seven persons aged 40-66 years participated. With MethodIND, the BP load, systolic, diastolic and mean BPs were higher in the daytime and lower in the night-time compared to the results using Method722 and MethodMEAN. The nocturnal BP fall using MethodIND was larger than the fall calculated from every possible fixed division in the period from 3 h before till 3 h after the group mean time of getting up and going to bed (p < 0.001). The lowest frequency of non-dipping, defined as a nightly fall in systolic and diastolic BP below 10%, was observed using MethodIND (10%). Compared to MethodIND, 11% were misclassified as non-dippers by Method722 and 8% by MethodMEAN. We conclude that the diurnal blood pressure variation based on individually defined periods of day and night is larger than the variation based on any collectively fixed day/night definition. It is recommended that assessment of the nocturnal change in BP be based on individually defined periods of day and night.