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Angiotensin converting enzyme inhibitor cough: lessons from heart-lung transplantation
E Gabbay1, T Small, P A Corris
1Department of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne, UK.
Respirology (Carlton, Vic.)
|July 10, 1998
Abstract:
Coughing is a frequent side-effect of angiotensin converting enzyme (ACE) inhibitors. Its pathogenesis is thought to be related to the local accumulation of tachykinins although the role of extrinsic cholinergic pathways is unclear. The development of an ACE inhibitor induced cough in two patients who have undergone heart-lung transplantation and in whom cholinergic pathways remain denervated supports the hypothesis of a 'local' mechanism.