Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipid peroxidation induced by shockwave lithotripsy

T D Cohen1, A F Durrani, S A Brown

  • 1Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Journal of Endourology
|July 11, 1998
PubMed
Summary

High-energy shockwave lithotripsy (SWL) increases lipid peroxidation in swine kidneys, potentially causing cellular damage. Detecting specific lipid hydroperoxides in urine may indicate kidney injury after SWL.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Global Precipitation Climatology Project (GPCP) Monthly Analysis (New Version 2.3) and a Review of 2017 Global Precipitation.

Atmosphere·2018
Same author

THE EARTH SYSTEM PREDICTION SUITE: Toward a Coordinated U.S. Modeling Capability.

Bulletin of the American Meteorological Society·2018
Same author

Minimizing radiation exposure during percutaneous nephrolithotomy.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology·2015
Same author

Surgical simulation using virtual reality technology: design, implementation, and implications.

Surgical technology international·2011
Same author

Advanced endoscopic imaging: 3-d laparoscopic endoscopy.

Surgical technology international·2011
Same author

In vivo determination of urinary stone composition using dual energy computerized tomography with advanced post-acquisition processing.

The Journal of urology·2010

Area of Science:

  • Biomedical Engineering
  • Nephrology
  • Biochemistry

Background:

  • Shockwave lithotripsy (SWL) is a common procedure for kidney stone removal.
  • Understanding the bioeffects of high-energy shockwaves (HESW) on renal tissue is crucial for patient safety.
  • Lipid peroxidation is a marker of cellular damage.

Purpose of the Study:

  • To investigate the relationship between HESW and lipid peroxidation products in kidneys.
  • To assess the potential of urinary lipid hydroperoxides as biomarkers of renal injury following SWL.

Main Methods:

  • Juvenile pigs underwent SWL, with treated and control kidneys analyzed.
  • Thiobarbituric acid-reactive substance (TBARS) and lipid-conjugated diene (CD) concentrations were measured in kidney homogenates and urine.

Related Experiment Videos

  • Urine samples were collected pre-, during, and post-SWL.

    • Main Results:

    • SWL significantly increased TBARS concentrations in kidney homogenates (146%) and cortex samples.
    • Increased CD concentrations (168%) were observed in the medulla of HESW-treated kidneys.
    • No significant differences in TBARS or CD were found in urine, but specific lipid hydroperoxides were detected in SWL-treated kidneys.

    Conclusions:

    • HESW lithotripsy is associated with increased lipid peroxidation in swine kidneys, potentially leading to cellular damage.
    • Lipid peroxidation induced by SWL may contribute to other bioeffects.
    • Urinary analysis of specific lipid hydroperoxides shows promise as a noninvasive marker for renal injury after clinical SWL.