[Brain-derived growth factor: current aspects]
T Serrano-Sánchez1, I Díaz-Armesto
1Centro Internacional de Restauración Neurológica, CIREN, La Habana, Cuba. teresa@neubas.sld.cu
Introduction:
The neurotrophins are a family of proteins which are closely related structurally and functionally and include nerve growth factor (NGF), brain derived nerve factor (BDNF) and neurotrophin-3 (NT-3), neurotrophin-4/5 (NT-4/5) and more recently neurotrophin-6 (NT-6). BDNF is one of the most important endogenous proteins for control of survival, growth and differentiation of certain neurone populations both in the peripheral and central nervous systems.
Development:
The ARNmt of the BDNF is found in nearly all regions of the brain. The highest levels are those of the hippocampus and cerebral cortex. The large number of effects attributed to BDNF are probably due to the union of this protein to its specific receptor on the cell surface, which leads to the formation of a complex which enables transmission of the signal caused by activation of the specific neurone pathway. Since discovery, BDNF has been detected and/or measured by different methods from biological assay to the application of molecular biology techniques. These methods have permitted analysis of the biochemical characteristics of this factor and its behaviour in different tissues.
Conclusions:
In this paper we review the most relevant aspects of distribution, biological actions of BDNF on different neurone populations, its clinical usefulness in neurological disorders, routes of administration and side effects.
More Related Videos
10:45Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
08:52Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
Published on: January 10, 2018
Related Concept Videos
Mitogens and the Cell Cycle
Regulation of Angiogenesis and Blood Supply
Regulation of Hematopoietic Stem Cells
TGF - β Signaling Pathway
Neurogenesis and Regeneration of Nervous Tissue
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
