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Related Experiment Videos

Gradient in convergent cell movement during Fundulus gastrulation

J P Trinkaus1

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, USA.

The Journal of Experimental Zoology
|July 11, 1998
PubMed
Summary

Cells in the Fundulus germ ring (GR) exhibit directed movement towards the embryonic shield (ES). Ventral GR cells meander more, showing less convergence, supporting a gradient of directional cues.

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Area of Science:

  • Developmental Biology
  • Cell Migration
  • Embryogenesis

Background:

  • Previous studies identified a gradient in convergent cell movement within the germ ring (GR) during Fundulus gastrulation.
  • Cells closer to the embryonic shield (ES) move faster due to less meandering.

Purpose of the Study:

  • To test the hypothesis of a gradient of cues directing cells to the ES.
  • To investigate the movement of ventral GR cells, which are farthest from the ES.

Main Methods:

  • Tracing individual cell trajectories in the midventral GR during mid-epiboly.
  • Observing and quantifying cell movement and meandering patterns.

Main Results:

  • Ventral GR cells exhibit similar motile behavior to dorsal cells but meander significantly more.

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  • Ventral GR cells show little to no directional movement toward the ES.
  • These findings support the existence of a gradient influencing directional cell migration.

    • Conclusions:

    • Cells in the germ ring move along a gradient of directionality as they converge towards the embryonic shield.
    • The embryonic shield likely acts as a chemoattractant, guiding cell migration.